Suppository Solid Provision Technology


  • Samuel Iwobi Department of Chemistry, Collage of Science and Technology, Covenant University, Nigeria



Suppository, Melting, Oleum


Suppository can be used for systemic effects in conditions where oral drug preparations will not be resistant or absorbed rapidly. Once inserted the base suppository melts, softens or dissolves causing the underlying medicinal substance to enter the tissues of the area. In the manufacture of suppositories, there is a term known as the exchange rate for making oleum cacao based. Therefore, weighing should not be carried out one by one, but the exchange rate of active substances is calculated to find the required oleum cacao. The advantage of weighing the ingredients is to provide the suppository period at the time of printing.


Allen, L. V. (1997). Suppositories as drug delivery systems. Journal of Pharmaceutical Care in Pain & Symptom Control, 5(2), 17-26.

de Blaey, C. J., & Fokkens, J. G. (1985). Drug release from suppositories. Pharmaceutical research, 2(2), 61-64.

de Vries, S. I., & ten Cate, J. W. (1969). Thrombopathy following use of Acetosal. Nederlands tijdschrift voor geneeskunde, 113(17), 752.

Ham, A. S., & Buckheit Jr, R. W. (2017). Designing and developing suppository formulations for anti-HIV drug delivery. Therapeutic delivery, 8(9), 805-817.

Hermann, T. W. (1995). Recent research on bioavailability of drugs from suppositories. International journal of pharmaceutics, 123(1), 1-11.

Hooker, G. D., Gregor, J. C., Ponich, T. P., & McLarty, T. D. (1996). Diaphragm-like strictures of the right colon induced by indomethacin suppositories: evidence of a systemic effect. Gastrointestinal endoscopy, 44(2), 199-202.

Liang, K., & Liang, L. (2002). U.S. Patent Application No. 09/974,452.

Santos, I. S., Ponte, B. M., Boonme, P., Silva, A. M., & Souto, E. B. (2013). Nanoencapsulation of polyphenols for protective effect against colon–rectal cancer. Biotechnology advances, 31(5), 514-523.

Yahata, T., Takedatsu, H., Dunwoodie, S. L., Bragança, J., Swingler, T., Withington, S. L., ... & Shioda, T. (2002). Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells. Genomics, 80(6), 601-613.