International Journal Papier Advance and Scientific Review http://igsspublication.com/index.php/ijpasr <p><strong>International Journal Papier Advance and Scientific Review </strong>ISSN <strong>2709-0248 </strong>covers research areas in Medical Science, Chemistry, Biology, Engineering, Technology, Information Sciences, Health Science, Applied Sciences, Cognitive Sciences, Artificial Intelligence, Life Sciences, Agricultural, Fisheries, Earth, Environmental Science, Botany, Zoology, Microbiology, Ecology, Ethnobiology, Genetics, Dental Health, Biochemistry, Bioinformatics, Biophysics, Biostatistics, Health Care Delivery, Health Care Research, Epidemiology, Midwifery, Health Psychology, Social Health, Biodiversity and Conservation Biology, Physical health, Quaternary Care, Secondary Care, Veterinary Nursing, Pharmaceutical Sciences, Hospital and Clinical Pharmacy, Architecture, Pathology, Physiotherapy &amp; Rehabilitation, Ergonomics, Food and Nutrition, Veterinary Medicines.</p> Information-Integrated Global Society Studies en-US International Journal Papier Advance and Scientific Review 2709-0248 The Effect of Coffee Consumption Behavior on Increased Blood Pressure http://igsspublication.com/index.php/ijpasr/article/view/111 <p>The purpose of this research is to establish whether or not coffee has an adverse impact on blood pressure. Analytic observation was used in this kind of study, which was carried out utilizing a cross-sectional methodology and analytic observation. The findings were similar with individuals who had never experienced hypertension. Also, the proportion of healthy individuals was greater. A research shows that coffee consumption raises blood pressure. The research comprised 42 people who drank coffee three times or more per day and had high blood pressure (80.7 of the time) The chi-square test revealed that coffee consumption raises blood pressure by p = 0.000</p> Karina Kaptelova Elena Pysanka Copyright (c) 2021 International Journal Papier Advance and Scientific Review https://creativecommons.org/licenses/by-sa/4.0/ 2021-10-07 2021-10-07 2 2 1 8 10.47667/ijpasr.v2i2.111 The Effect of Trehalose in Inhibiting Liver Damage via The Il-6 Pathway in Old Mice http://igsspublication.com/index.php/ijpasr/article/view/112 <p>Trehalose is a non-reducing disaccharide consisting of two glucose molecules linked by a 1–1 glycosidic bond. Trehalose can play a role in organ detoxification, antioxidant enzyme activity, reducing lipid peroxidation and reducing the secretion of inflammatory factors TNF-, IL-1β, Il-6, thereby inhibiting liver damage. Because of its role, this study aims to determine the effect of trehalose administration on liver damage through the IL-6 expression pathway with experimental post-test design with control group design. This research was conducted using samples of old rats, namely Wistar rats (Rattus novergicus). The old rats used were 21 male species which were then divided into 3 groups, namely the old control group, the old rat group that was given sucrose, and the old rat group that was given trehalose. Then observed for 8 weeks, namely in March - May 2021 at the Faculty of Medicine, Hasanuddin University Makassar. The results obtained from the 3 groups showed a significant value that the administration of trehalose sugar in elderly mice had an effect on reducing the inflammatory factor IL-6 because it activated autophagy in macrophages thereby reducing cytokine production and vascular inflammation so as to be able to restore all aging mice to a level like observed in young mice. It is also known that aged rat liver, which is characterized by ER UPR activation and inflammatory signaling, decreases nicotinamide and UDP-N-acetyl-hexosamines, and reduces proteasome activity. Therefore, trehalose can be an effective therapeutic strategy against age-related disorders of proteostasis in the liver.</p> Rabiatul Aminah Arif Santoso Muh Husni Cangara Marhaen Hardjo Aminuddin Aminuddin Endy Adnan Copyright (c) 2021 International Journal Papier Advance and Scientific Review https://creativecommons.org/licenses/by-sa/4.0/ 2021-10-07 2021-10-07 2 2 9 19 10.47667/ijpasr.v2i2.112 Effect of Rumen Fluid Dosage and Fermentation Time on Dissolved Protein Levels of Vegetable Waste Silage for Vannamei Shrimp Feed http://igsspublication.com/index.php/ijpasr/article/view/110 <p>Specifically, the goal of this research was to evaluate the dissolved protein content of vegetable waste generated during the incubation of rumen fluid for use in (Whiteleg) vannamei shrimp diet. The results of the analysis of the degree of protein hydrolysis of vegetable waste treated with the addition of rumen fluid enzymes and different fermentation times of rumen fluid revealed that the addition of rumen fluid enzymes and different fermentation times of rumen fluid had a statistically significant effect (p0.05) on the degree of protein hydrolysis of vegetable waste. But there was no significant difference in the length of fermentation time or the interaction between the dosage of rumen fluid and the length of time (p&gt;0.05) between the two groups. Duncan's test of rumen fluid dosage revealed that the degree of hydrolysis at a 1 percent dose was considerably greater (p0.05) than at 2 percent and 3 percent doses, and that the degree of hydrolysis at a 3 percent dose was significantly lower than at 2 percent</p> Brenda Munyiva Wahu Oyaya Mumbi Wanjiku Koech Copyright (c) 2021 International Journal Papier Advance and Scientific Review https://creativecommons.org/licenses/by-sa/4.0/ 2021-10-07 2021-10-07 2 2 20 24 10.47667/ijpasr.v2i2.110 Progress in Lowering the Number of Malnutrition Cases in Toddlers in Bone Regency, South Sulawesi http://igsspublication.com/index.php/ijpasr/article/view/116 <p style="user-select: auto;"><em style="user-select: auto;">This study aims to analyze the factors, thus advancement Kab. Bone in lowering malnutrition case in Toddler. This research uses qualitative research with a case study approach. Data were obtained by in-depth interviews and unstructured observations to 22 resource persons consisting of health workers, policy makers (stake holder), community leaders and cadres. Study results shows that all puskesmas carry out the PSG program, moreover the health worker perform the duties with positive attitude and good awareness. Availability of human resources for health care services for malnourished toddlers is 2-4 people, therefore at posyandu helped by 2-5 cadres. As well as support from stakeholder, and good participation from the community. However, there still a lack of knowledge from the community leaders, and cadres about PSG work program. Moreover, there is a shortfall for the availability of health worker in undernourished toddler, also the lack of awareness by some health workers towards teamwork. Inconclusion, the work program, attitude and health worker awareness, human resource availability, stake holder support, and community participation is proven to play a role in progress to reduce the number of cases of malnutrition at Kab. Bone. Stakeholders are expected to make new adaptations or innovations to adjust to the situation during the Covid-19 pandemic, improve the teamwork system, add health workers who serve in undernourished toddlers, and increase more massive and active socialization about the PSG program</em></p> Zhery Mulyati Sudirman Nasir Ridwan Mochtar Thaha Copyright (c) 2021 International Journal Papier Advance and Scientific Review https://creativecommons.org/licenses/by-sa/4.0/ 2021-10-28 2021-10-28 2 2 25 37 10.47667/ijpasr.v2i2.116 Factors Associated with 0-28 Day Neonatal Mortality in Central Aceh Regency http://igsspublication.com/index.php/ijpasr/article/view/123 <p>This study aims to determine the factors associated with neonatal mortality 0-28 days in Central Aceh District in 2020. This research is a quantitative study with a case control research design and uses a retrospective approach. The study population was all mothers giving birth whose babies died at the age of 0-28 days from January to December 2020. The sample in this study was 120 respondents consisting of 60 cases and 60 controls. The sampling technique used was total sampling. Data analysis using chi square test and multiple logistic regression test. The results of the bivariate analysis using the chi square test showed that there were 2 variables that were significantly related to neonatal mortality, namely the maternal age variable with p value = 0.012 and the pregnancy examination variable with p value = 0.047. The results of multivariate analysis with multiple logistic regression test showed that there were 3 variables that influenced neonatal mortality, namely the maternal age variable with a p value of 0.001, the birth spacing variable with a p value of 0.018 and the pregnancy examination variable with a p value of 0.018, while the most dominant variable affecting the incidence of death Neonatal age is the variable of maternal age with an OR value of 4.397.</p> Asriwati Amirah Thomson P Nadapdap Suryani Suryani Copyright (c) 2021 International Journal Papier Advance and Scientific Review https://creativecommons.org/licenses/by-sa/4.0/ 2021-12-09 2021-12-09 2 2 38 49 10.47667/ijpasr.v2i2.123 Analysis of Lut Tawar Health Center Service Quality on Outpatient Patient Satisfaction in Central Aceh Regency http://igsspublication.com/index.php/ijpasr/article/view/122 <p>The purpose of this study was to find out what aspects were related to the quality of service at the Lut Tawar Health Center to the Satisfaction of Outpatients in Central Aceh Regency. The research design used in this study was Cross Sectional. The population in this study was 7,507 people and the samples taken by accidental sampling were 99 people. Data collection methods are primary data and secondary data. Analysis of the data used is a binary logistic regression test. The results showed that the physical condition had a sig-p value of 0.004 &lt; 0.05, reliability sig-p 0.004 &lt; 0.005, and a sig-p guarantee of 0.030 &lt; 0.05, which means that it has a relationship with the quality of health services, while responsiveness has no relationship to the quality of health services because it has a sig-p value of 0.173 &gt; 0.05 and concern has no relationship to the quality of health services because it has a sig-p value of 0.893 &gt; 0.05. The most dominant aspect related to service quality is the variable of physical condition p = 0.004 &lt;0.05. The conclusion in this study is that there is a relationship between physical condition, reliability, and assurance on the quality of Community Health Center (puskesmas) services, while the responsiveness and caring variables have no relationship to the quality of puskesmas services.</p> Asriwati Amirah Mappeaty Nyorong Wahyu Fatrah Nananda Copyright (c) 2021 International Journal Papier Advance and Scientific Review https://creativecommons.org/licenses/by-sa/4.0/ 2021-12-13 2021-12-13 2 2 50 58 10.47667/ijpasr.v2i2.122 Aloe Vera Extract For Stomach Acid Use Safe And Effective Treatment http://igsspublication.com/index.php/ijpasr/article/view/125 <p>The purpose of this study was to determine the effectiveness of aloe vera juice against stomach acid. Aloe vera also contains key elements such as resin, aloin, tannins, aloin-emodin, polysaccharides, 19 amino acids, 12 vitamins and 20 minerals that are important for health. Aloe vera is a natural ingredient that is good for detoxifying heavy metals in the body, and is able to maximize the performance of the digestive system. consuming aloe vera juice in a certain dose, is very effective for healing wounds in the stomach, as well as being a natural remedy for stomach ulcers which is quite effective. Aloe vera has the ability to stimulate the release of pepsin, which is an enzyme in the stomach that works to support the digestive system</p> Alexendru Retiu Tenase Budescu Iaoani Menae Copyright (c) 2021 International Journal Papier Advance and Scientific Review https://creativecommons.org/licenses/by-sa/4.0/ 2021-12-20 2021-12-20 2 2 59 64 10.47667/ijpasr.v2i2.125 The Effect of Workload on the Performance of Nurses in the Inpatient Installation of RSUP Dr. Tadjuddin Chalid Makassar http://igsspublication.com/index.php/ijpasr/article/view/126 <p>Performance is work performance or work results in quality and quantity achieved by an employee in carrying out his duties in accordance with the responsibilities given to him. This study aims to analyze the effect of workload on the performance of nurses in the Inpatient Installation of Dr. RSUP. Tajuddin Chalid Makassar. This type of research is a quantitative research using an observational study with a cross sectional study design. Sampling used total sampling so that the sample in this study were nurses at the Inpatient Installation of Dr. RSUP. Tajuddin Chalid Makassar, totaling 73 respondents. The results showed that there was an effect of time load on the performance of nurses, there was an effect of physical burden on the performance of nurses. there is an effect of psychological pressure on the performance of nurses in the Inpatient Installation of Dr. RSUP. Tajuddin Chalid Makassar. Therefore, it is hoped that the hospital management will increase the knowledge and skills of nurses so that they are able to compensate for the difficult work through providing training, the need to improve nursing management by making SOPs, especially the division of tasks and working hours of nurses so that they can be adjusted to the nurse's workload</p> Andi Niartiningsih Anis Khairunnisa Nurul Hidayah Nur Copyright (c) 2021 International Journal Papier Advance and Scientific Review https://creativecommons.org/licenses/by-sa/4.0/ 2021-12-20 2021-12-20 2 2 65 71 10.47667/ijpasr.v2i2.126 Design and Implementation of Smart Bench Integrated Solar Cell for Public Space Electricity Saving http://igsspublication.com/index.php/ijpasr/article/view/121 <p>The purpose of this research is to design a multifunctional garden bench integrated with solar panels. The bench product is created by utilizing sunlight as a source of electrical energy for the object features of the bench product. The implementation method for producing innovative bench products uses a research and development approach, including concept, design, collection of materials, assembly, and testing. The bench was tested to supply electricity to the LED lights and USB ports. Furthermore, analyzing statistical data the average value of; current, voltage, and power generated by the intelligent bench object. The study results present the primary resources needed for the design and implementation of intelligent bench products. Experiments show that a load of LED lights and USB station chargers depends on the percentage of battery batteries supplied from solar cells. The innovative bench is designed from hollow steel to support product construction efficiency and electronic effectiveness. In this way, we achieved our goal of designing and implementing a portable garden bench that could function in all open areas.</p> Riklan Kango Hadiyanto Hadiyanto Ezra Hartarto Pongtuluran Copyright (c) 2021 International Journal Papier Advance and Scientific Review https://creativecommons.org/licenses/by-sa/4.0/ 2021-12-22 2021-12-22 2 2 72 81 10.47667/ijpasr.v2i2.121 Sweet Potato Leaves Contain Beta Carotene and Lutein for Eye Health http://igsspublication.com/index.php/ijpasr/article/view/128 <p>This article discusses the benefits of sweet potato leaves containing beta carotene and lutein for eye health. There are some problems of eyes namely Conjunctivitis, Dry Eyes , Cataract, Glaucoma and Refractive errors (blurred vision). Treatment options include surgery, including laser and traditional eye surgery. Sweet potatoes are high in beta-carotene and anthocyanins, which are powerful antioxidants that can help prevent eyesight loss and support eye health. Beta carotene (provitamin A) and vitamin C are plentiful in yellow sweet potato. The beta carotene and lutein content is beneficial for eye health.</p> Kepaito Mandela Evaire Shakave Copyright (c) 2021 International Journal Papier Advance and Scientific Review https://creativecommons.org/licenses/by-sa/4.0/ 2021-12-22 2021-12-22 2 2 82 89 10.47667/ijpasr.v2i2.128 Analysis of the Implementation of the Regulation of the Minister of Health Number 44 of 2016 concerning Public Health Center Management http://igsspublication.com/index.php/ijpasr/article/view/130 <div><span lang="EN-US">The Regulation of the Minister of Health of Indonesia Number 44 of 2016 provides guidelines for puskesmas so that they can apply the puskesmas management pattern properly and correctly. The initial data obtained by the Pegasing Health Center has not fully implemented the Regulation of the Minister of Health of the Republic of Indonesia Number 44 of 2016 concerning management guidelines. The purpose of the study was to analyze the implementation of the Minister of Health Regulation Number 44 of 2016 concerning Public Health Center management at Pegasing Public Health Center, Central Aceh Regency. The research design used qualitative methods. The informant was the head of the puskesmas, the head of administration, the head of the admin, the head of the UKP, and the head of the UKM. The data were analyzed through the stages of reduction, data presentation and drawing conclusions. The results showed that planning, mobilization and implementation, monitoring control and performance appraisal were not carried out according to the Minister of Health No. 44 of 2016, the commitment was there but not all staff knew, the management team had not been formed, there was still a lack of staff awareness regarding the Minister of Health No. 44 of 2016. The conclusion of this study is that the Minister of Health Regulation No. 44 of 2016 does not work, organizational commitment has not been socialized, there is no management team formation, lack of concern, lack of solid team work. lack of staff knowledge and employee responsibilities.</span></div> Ismail Efendy Mappeaty Nyorong Himmah Himmah Copyright (c) 2021 International Journal Papier Advance and Scientific Review https://creativecommons.org/licenses/by-sa/4.0/ 2021-12-30 2021-12-30 2 2 90 104 10.47667/ijpasr.v2i2.130 Factors Affecting the Incidence of Uncontrolled Hypertension in Patients Performing Routine Examinations at the Kebayakan Public Health Center, Central Aceh Regency http://igsspublication.com/index.php/ijpasr/article/view/131 <p>The purpose of the study was to determine the factors that influence the incidence of uncontrolled hypertension in patients who carry out routine checks at the Community Health Center (Puskesmas). Method: using analytical survey method using Case Control research design. The sample was 148 respondents, 74 case groups and 74 control groups were taken by purposive sampling. Data analysis was performed univariate, bivariate and multivariate with multiple logistic regression. The results of the bivariate test showed that the factors influencing the incidence of uncontrolled hypertension were age (p= 0.002; OR = 3,253), family history (p= 0.000; OR = 4.216), obesity (p= 0.005; OR = 2.734), physical activity (p= 0.000; OR = 4.229), salt consumption (p= 0.000; OR = 4,127), coffee consumption (p= 0.010; OR = 4,127), stress (p= 0.000; OR = 3,745), medication adherence (p= 0.000; OR = 4.492). Factors that were not related were gender (p= 0.620; OR = 0.803), smoking (p= 1,000; OR = 1,000). While the results of the multivariate test showed that the most influential factors with the incidence of uncontrolled hypertension were medication adherence variable (p= 0.000; Exp(B) = 5.982), and obesity variable (p= 0.002; Exp(B) = 4.945). In conclusion, the dominant factors that influence the incidence of uncontrolled hypertension at the Kebayakan Health Center are medication adherence and obesity.</p> Thomson P. Nadapdap Zuraidah Nasution Indra Wahyudi Copyright (c) 2021 International Journal Papier Advance and Scientific Review https://creativecommons.org/licenses/by-sa/4.0/ 2021-12-30 2021-12-30 2 2 105 116 10.47667/ijpasr.v2i2.131