The Effect of Trehalose in Inhibiting Liver Damage via The Il-6 Pathway in Old Mice

Authors

  • Rabiatul Aminah Department of Biomedic, Post Graduate School, Hasanuddin Univesity, Indonesia
  • Arif Santoso Department of Biomedic, Post Graduate School, Hasanuddin Univesity, Indonesia
  • Muh Husni Cangara Department of Biomedic, Post Graduate School, Hasanuddin Univesity, Indonesia
  • Marhaen Hardjo Department of Biomedic, Post Graduate School, Hasanuddin Univesity, Indonesia
  • Aminuddin Aminuddin Department of Nutrition, Faculty of Medicine Hasanuddin University and Hasanuddin Hospital, Indonesia
  • Endy Adnan Department of Biomedic, Post Graduate School, Hasanuddin Univesity, Indonesia

DOI:

https://doi.org/10.47667/ijpasr.v2i2.112

Keywords:

Trehalose, Aging, Inflammation

Abstract

Trehalose is a non-reducing disaccharide consisting of two glucose molecules linked by a 1–1 glycosidic bond. Trehalose can play a role in organ detoxification, antioxidant enzyme activity, reducing lipid peroxidation and reducing the secretion of inflammatory factors TNF-, IL-1β, Il-6, thereby inhibiting liver damage. Because of its role, this study aims to determine the effect of trehalose administration on liver damage through the IL-6 expression pathway with experimental post-test design with control group design. This research was conducted using samples of old rats, namely Wistar rats (Rattus novergicus). The old rats used were 21 male species which were then divided into 3 groups, namely the old control group, the old rat group that was given sucrose, and the old rat group that was given trehalose. Then observed for 8 weeks, namely in March - May 2021 at the Faculty of Medicine, Hasanuddin University Makassar. The results obtained from the 3 groups showed a significant value that the administration of trehalose sugar in elderly mice had an effect on reducing the inflammatory factor IL-6 because it activated autophagy in macrophages thereby reducing cytokine production and vascular inflammation so as to be able to restore all aging mice to a level like observed in young mice. It is also known that aged rat liver, which is characterized by ER UPR activation and inflammatory signaling, decreases nicotinamide and UDP-N-acetyl-hexosamines, and reduces proteasome activity. Therefore, trehalose can be an effective therapeutic strategy against age-related disorders of proteostasis in the liver.

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Published

2021-10-07

How to Cite

Aminah, R., Santoso, A. ., Cangara, M. H. ., Hardjo, M. ., Aminuddin, A. ., & Adnan, E. . (2021). The Effect of Trehalose in Inhibiting Liver Damage via The Il-6 Pathway in Old Mice. International Journal Papier Advance and Scientific Review, 2(2), 9-19. https://doi.org/10.47667/ijpasr.v2i2.112