The Effect of Trehalose in Inhibiting Liver Damage via The Il-6 Pathway in Old Mice
Keywords:Trehalose, Aging, Inflammation
Trehalose is a non-reducing disaccharide consisting of two glucose molecules linked by a 1–1 glycosidic bond. Trehalose can play a role in organ detoxification, antioxidant enzyme activity, reducing lipid peroxidation and reducing the secretion of inflammatory factors TNF-, IL-1β, Il-6, thereby inhibiting liver damage. Because of its role, this study aims to determine the effect of trehalose administration on liver damage through the IL-6 expression pathway with experimental post-test design with control group design. This research was conducted using samples of old rats, namely Wistar rats (Rattus novergicus). The old rats used were 21 male species which were then divided into 3 groups, namely the old control group, the old rat group that was given sucrose, and the old rat group that was given trehalose. Then observed for 8 weeks, namely in March - May 2021 at the Faculty of Medicine, Hasanuddin University Makassar. The results obtained from the 3 groups showed a significant value that the administration of trehalose sugar in elderly mice had an effect on reducing the inflammatory factor IL-6 because it activated autophagy in macrophages thereby reducing cytokine production and vascular inflammation so as to be able to restore all aging mice to a level like observed in young mice. It is also known that aged rat liver, which is characterized by ER UPR activation and inflammatory signaling, decreases nicotinamide and UDP-N-acetyl-hexosamines, and reduces proteasome activity. Therefore, trehalose can be an effective therapeutic strategy against age-related disorders of proteostasis in the liver.
Chronic IL-6 administration desensitizes IL-6 response in liver, causes hyperleptinemia and aggravates steatosis in diet-induced-obese mice. PLoS ONE, 11(6), 1–19. https://doi.org/10.1371/journal.pone.0157956
Gavito, A. L., Bautista, D., Suarez, J., Badran, S., Arco, R., Pavón, F. J., Serrano, A., Rivera, P., Decara, J., Cuesta, A. L., Rodríguez-de-Fonseca, F., & Baixeras, E. (2016)
Maulina, M. (2018). Zat-Zat yang Mempengaruhi Histopatologi Hepar. In D. Al-Muqsith (Ed.), Unimal Press (Pertama). Unimal Press
Moeini, A., Pedram, P., Makvandi, P., Malinconico, M., & d'Ayala, G. G. (2020). Wound healing and antimicrobial effect of active secondary metabolites in chitosan-based wound dressings: A review. Carbohydrate polymers, 233, 115839.
Pagliassotti, M. J., Estrada, A. L., Hudson, W. M., Wei, Y., Seals, D. R., Zigler, M. L., Larocca, T. J., Nutrition, H., & Collins, F. (2017). Trehalose Supplementation Reduces Hepatic Endoplasmic Reticulum Stress and Inflammatory Signaling in Old Mice. J Nutr Biochem, 45, 15–23. https://doi.org/10.1016/j.jnutbio.2017.02.022
Rezabakhsh, A., Rahbarghazi, R., Malekinejad, H., Fathi, F., Montaseri, A., & Garjani, A. (2019). Quercetin alleviates high glucose-induced damage on human umbilical vein endothelial cells by promoting autophagy. Phytomedicine, 56, 183-193
Susantiningsih, T., & Mustofa, S. (2018). Ekspresi IL-6 dan TNF- α Pada Obesitas. Jurnal Kedokteran Unila, 2(2), 174–180
Tanner, J. E., & Alfieri, C. (2021). The fatty acid lipid metabolism nexus in COVID-19. Viruses, 13(1), 90
Tonini, C., Segatto, M., Bertoli, S., Leone, A., Mazzoli, A., Cigliano, L., ... & Pallottini, V. (2021). Prenatal Exposure to BPA: The Effects on Hepatic Lipid Metabolism in Male and Female Rat Fetuses. Nutrients, 13(6), 1970
Zhang, L., Li, F., Guo, Q., Duan, Y., Wang, W., Yang, Y., ... & Yin, Y. (2021). Different Proportions of Branched-Chain Amino Acids Modulate Lipid Metabolism in a Finishing Pig Model. Journal of Agricultural and Food Chemistry.
How to Cite
Copyright (c) 2021 International Journal Papier Advance and Scientific Review
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.