International Journal Papier Advance and Scientific Review 2021-10-28T10:29:03+07:00 Open Journal Systems <p><strong>International Journal Papier Advance and Scientific Review </strong>ISSN <strong>2709-0248 </strong>covers research areas in Medical Science, Chemistry, Biology, Engineering, Technology, Information Sciences, Health Science, Applied Sciences, Cognitive Sciences, Artificial Intelligence, Life Sciences, Agricultural, Fisheries, Earth, Environmental Science, Botany, Zoology, Microbiology, Ecology, Ethnobiology, Genetics, Dental Health, Biochemistry, Bioinformatics, Biophysics, Biostatistics, Health Care Delivery, Health Care Research, Epidemiology, Midwifery, Health Psychology, Social Health, Biodiversity and Conservation Biology, Physical health, Quaternary Care, Secondary Care, Veterinary Nursing, Pharmaceutical Sciences, Hospital and Clinical Pharmacy, Architecture, Pathology, Physiotherapy &amp; Rehabilitation, Ergonomics, Food and Nutrition, Veterinary Medicines.</p> The Effect of Coffee Consumption Behavior on Increased Blood Pressure 2021-10-04T13:27:07+07:00 Karina Kaptelova Elena Pysanka <p>The purpose of this research is to establish whether or not coffee has an adverse impact on blood pressure. Analytic observation was used in this kind of study, which was carried out utilizing a cross-sectional methodology and analytic observation. The findings were similar with individuals who had never experienced hypertension. Also, the proportion of healthy individuals was greater. A research shows that coffee consumption raises blood pressure. The research comprised 42 people who drank coffee three times or more per day and had high blood pressure (80.7 of the time) The chi-square test revealed that coffee consumption raises blood pressure by p = 0.000</p> 2021-10-07T00:00:00+07:00 Copyright (c) 2021 International Journal Papier Advance and Scientific Review The Effect of Trehalose in Inhibiting Liver Damage via The Il-6 Pathway in Old Mice 2021-10-04T13:31:58+07:00 Rabiatul Aminah Arif Santoso Muh Husni Cangara Marhaen Hardjo Aminuddin Aminuddin Endy Adnan <p>Trehalose is a non-reducing disaccharide consisting of two glucose molecules linked by a 1–1 glycosidic bond. Trehalose can play a role in organ detoxification, antioxidant enzyme activity, reducing lipid peroxidation and reducing the secretion of inflammatory factors TNF-, IL-1β, Il-6, thereby inhibiting liver damage. Because of its role, this study aims to determine the effect of trehalose administration on liver damage through the IL-6 expression pathway with experimental post-test design with control group design. This research was conducted using samples of old rats, namely Wistar rats (Rattus novergicus). The old rats used were 21 male species which were then divided into 3 groups, namely the old control group, the old rat group that was given sucrose, and the old rat group that was given trehalose. Then observed for 8 weeks, namely in March - May 2021 at the Faculty of Medicine, Hasanuddin University Makassar. The results obtained from the 3 groups showed a significant value that the administration of trehalose sugar in elderly mice had an effect on reducing the inflammatory factor IL-6 because it activated autophagy in macrophages thereby reducing cytokine production and vascular inflammation so as to be able to restore all aging mice to a level like observed in young mice. It is also known that aged rat liver, which is characterized by ER UPR activation and inflammatory signaling, decreases nicotinamide and UDP-N-acetyl-hexosamines, and reduces proteasome activity. Therefore, trehalose can be an effective therapeutic strategy against age-related disorders of proteostasis in the liver.</p> 2021-10-07T00:00:00+07:00 Copyright (c) 2021 International Journal Papier Advance and Scientific Review Effect of Rumen Fluid Dosage and Fermentation Time on Dissolved Protein Levels of Vegetable Waste Silage for Vannamei Shrimp Feed 2021-10-04T13:24:49+07:00 Brenda Munyiva Wahu Oyaya Mumbi Wanjiku Koech <p>Specifically, the goal of this research was to evaluate the dissolved protein content of vegetable waste generated during the incubation of rumen fluid for use in (Whiteleg) vannamei shrimp diet. The results of the analysis of the degree of protein hydrolysis of vegetable waste treated with the addition of rumen fluid enzymes and different fermentation times of rumen fluid revealed that the addition of rumen fluid enzymes and different fermentation times of rumen fluid had a statistically significant effect (p0.05) on the degree of protein hydrolysis of vegetable waste. But there was no significant difference in the length of fermentation time or the interaction between the dosage of rumen fluid and the length of time (p&gt;0.05) between the two groups. Duncan's test of rumen fluid dosage revealed that the degree of hydrolysis at a 1 percent dose was considerably greater (p0.05) than at 2 percent and 3 percent doses, and that the degree of hydrolysis at a 3 percent dose was significantly lower than at 2 percent</p> 2021-10-07T00:00:00+07:00 Copyright (c) 2021 International Journal Papier Advance and Scientific Review Progress in Lowering the Number of Malnutrition Cases in Toddlers in Bone Regency, South Sulawesi 2021-10-28T10:29:03+07:00 Zhery Mulyati Sudirman Nasir Ridwan Mochtar Thaha <p style="user-select: auto;"><em style="user-select: auto;">This study aims to analyze the factors, thus advancement Kab. Bone in lowering malnutrition case in Toddler. This research uses qualitative research with a case study approach. Data were obtained by in-depth interviews and unstructured observations to 22 resource persons consisting of health workers, policy makers (stake holder), community leaders and cadres. Study results shows that all puskesmas carry out the PSG program, moreover the health worker perform the duties with positive attitude and good awareness. Availability of human resources for health care services for malnourished toddlers is 2-4 people, therefore at posyandu helped by 2-5 cadres. As well as support from stakeholder, and good participation from the community. However, there still a lack of knowledge from the community leaders, and cadres about PSG work program. Moreover, there is a shortfall for the availability of health worker in undernourished toddler, also the lack of awareness by some health workers towards teamwork. Inconclusion, the work program, attitude and health worker awareness, human resource availability, stake holder support, and community participation is proven to play a role in progress to reduce the number of cases of malnutrition at Kab. Bone. Stakeholders are expected to make new adaptations or innovations to adjust to the situation during the Covid-19 pandemic, improve the teamwork system, add health workers who serve in undernourished toddlers, and increase more massive and active socialization about the PSG program</em></p> 2021-10-28T00:00:00+07:00 Copyright (c) 2021 International Journal Papier Advance and Scientific Review