Synthesis of Heterocyclic Compounds Via Chalcone Derivatives and Study Activity of Some these Compounds as Pesticides (Anti-Dubas)

Authors

  • Tiba Ibrahim Mohammed Department of Chemistry , College of Science , University of Al-Qadisiyah, Iraq
  • Shurooq Abbas Hassan Muthanna Agriculture Directorate, Ministry of Agriculture, Al-Muthanna, Iraq
  • Abbas K. Abbas Muthanna Agriculture Directorate, Ministry of Agriculture, Al-Muthanna, Iraq
  • Rawaa N. Abdulazeez Muthanna Agriculture Directorate, Ministry of Agriculture, Al-Muthanna, Iraq

DOI:

https://doi.org/10.47667/ijpasr.v4i2.207

Keywords:

Chalcone, Oxazine, Thiazine, Insects, Insecticides

Abstract

In this research, we synthesized oxazine and thiazine derivatives (3-6). These derivatives of chacone compounds (1 and 2) that synthesized from 4- hydroxyacetophenone and aldehyde derivatives such as, 4-bromobenzaldehyde and 4- chlorobenzaldehyde. These derivatives of chalcone (1-2) reacted with urea to produce oxazine derivatives as 4-[4-amino-6-(4-subsutitedphenyl)-2H-1,3-oxazin-2-yl] phenol (3 and 4) and thiourea to produce 4-[4-amino-6-(4-subsutitedphenyl)-2H-1,3-thiazin-2-yl] phenol (5 and 6). These derivatives were characterization by spectroscopy methods such as, FTIR and 1HNMR. Some compounds (3 and 5) that synthesized tested as Pesticides (anti-dubas) through the spray method and these derivatives killed Dubas and we noted the compound 5 was more active from compound 3 because compound 5 have been S atom in his structure that bonded in active group in dubas by effect on Cholinesterase enzyme in the insect.

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References

Barrantes, K., Araya, J. J., Chacón, L., Procupez‐Schtirbu, R., Lugo, F., Ibarra, G., & Soto, V. H. (2021). Antiviral, Antimicrobial, and Antibiofilm Properties of Biosurfactants: Sustainable Use in Food and Pharmaceuticals. Biosurfactants for a Sustainable Future: Production and Applications in the Environment and Biomedicine, 245-268.

Borrer, D. J., & Delong, D. M. (1954). An Introduction to the Sudy of Insects (Vol. 78, No. 5, p. 406). LWW.

Didwagh, S. S., & Piste, P. B. (2013). Green synthesis of thiazine and oxazine derivatives-a short review. Int J Pharm Sci Res, 4(6), 2045.

Didwagh, S. S., & Piste, P. B. (2013). Novel synthesis and antimicrobial activity of bis-oxazine derivatives. Journal of Chemical and Pharmaceutical Research, 5(5), 271-274.

Didwagh, S. S., & Piste, P. B. (2013). Synthesis and antimicrobial activity of thiazine derivatives. Journal of Chemical and Pharmaceutical Research, 55, 171-174.

Gupta, R. C. (Ed.). (2019). Biomarkers in toxicology. Academic press.

Katz, M. (1998). Organic Chemistry, (Bruice, Paula Y.).

Lihumis, H. S., Mubarak, H. A., Alameri, A. A., & Aowda, S. A. (2022). Synthesis and Diagnosis of Some New Heterocyclic Compounds from Mefenamic Drug and Study of Their Possible Biological Activity.

Mandge, S., Singh, H. P., Gupta, S. D., & Moorthy, N. H. S. N. (2007). Synthesis and characterization of some chalcone derivatives. Trends Appl. Sci. Res, 2(1), 52-56.

Morak-Młodawska, B., Pluta, K., Latocha, M., Jeleń, M., Kuśmierz, D., Suwińska, K., ... & Jurzak, M. (2019). 10 H-1, 9-diazaphenothiazine and its 10-derivatives: synthesis, characterisation and biological evaluation as potential anticancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry, 34(1), 1298-1306.

Nasir Abbas Bukhari, S., Jasamai, M., & Jantan, I. (2012). Synthesis and biological evaluation of chalcone derivatives (mini review). Mini reviews in medicinal chemistry, 12(13), 1394-1403.

Sabre, H. M. (2022). Synthesis and Characterization of Some Novel Oxazine and Thiazine from Acetophenone Derivatives. Journal of Global Scientific Research, 7(4), 2240-2246.

Sadhu, C., & Mitra, A. K. (2023). Synthetic, biological and optoelectronic properties of phenoxazine and its derivatives: a state of the art review. Molecular Diversity, 1-43.

SCHMIDT, R. R. (1972). 1, 3-Oxazines and 1, 3-thiazines, intermediates of interest in organic syntheses. Synthesis, 1972(07), 333-350‏

Sharma, B. K. (1981). Spectroscopy. Krishna Prakashan Media.

Sharma, Y. R. (2007). Elementary organic spectroscopy. S. Chand Publishing.

Zhuang, C., Zhang, W., Sheng, C., Zhang, W., Xing, C., & Miao, Z. (2017). Chalcone: a privileged structure in medicinal chemistry. Chemical reviews, 117(12), 7762-7810.

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Published

2023-05-17

How to Cite

Mohammed, T. I., Hassan, S. A., Abbas, A. K., & Abdulazeez, R. N. (2023). Synthesis of Heterocyclic Compounds Via Chalcone Derivatives and Study Activity of Some these Compounds as Pesticides (Anti-Dubas). International Journal Papier Advance and Scientific Review, 4(2), 1-9. https://doi.org/10.47667/ijpasr.v4i2.207