Synthesis of Heterocyclic Compounds Via Chalcone Derivatives and Study Activity of Some these Compounds as Pesticides (Anti-Dubas)
Keywords:Chalcone, Oxazine, Thiazine, Insects, Insecticides
In this research, we synthesized oxazine and thiazine derivatives (3-6). These derivatives of chacone compounds (1 and 2) that synthesized from 4- hydroxyacetophenone and aldehyde derivatives such as, 4-bromobenzaldehyde and 4- chlorobenzaldehyde. These derivatives of chalcone (1-2) reacted with urea to produce oxazine derivatives as 4-[4-amino-6-(4-subsutitedphenyl)-2H-1,3-oxazin-2-yl] phenol (3 and 4) and thiourea to produce 4-[4-amino-6-(4-subsutitedphenyl)-2H-1,3-thiazin-2-yl] phenol (5 and 6). These derivatives were characterization by spectroscopy methods such as, FTIR and 1HNMR. Some compounds (3 and 5) that synthesized tested as Pesticides (anti-dubas) through the spray method and these derivatives killed Dubas and we noted the compound 5 was more active from compound 3 because compound 5 have been S atom in his structure that bonded in active group in dubas by effect on Cholinesterase enzyme in the insect.
Barrantes, K., Araya, J. J., Chacón, L., Procupez‐Schtirbu, R., Lugo, F., Ibarra, G., & Soto, V. H. (2021). Antiviral, Antimicrobial, and Antibiofilm Properties of Biosurfactants: Sustainable Use in Food and Pharmaceuticals. Biosurfactants for a Sustainable Future: Production and Applications in the Environment and Biomedicine, 245-268.
Borrer, D. J., & Delong, D. M. (1954). An Introduction to the Sudy of Insects (Vol. 78, No. 5, p. 406). LWW.
Didwagh, S. S., & Piste, P. B. (2013). Green synthesis of thiazine and oxazine derivatives-a short review. Int J Pharm Sci Res, 4(6), 2045.
Didwagh, S. S., & Piste, P. B. (2013). Novel synthesis and antimicrobial activity of bis-oxazine derivatives. Journal of Chemical and Pharmaceutical Research, 5(5), 271-274.
Didwagh, S. S., & Piste, P. B. (2013). Synthesis and antimicrobial activity of thiazine derivatives. Journal of Chemical and Pharmaceutical Research, 55, 171-174.
Gupta, R. C. (Ed.). (2019). Biomarkers in toxicology. Academic press.
Katz, M. (1998). Organic Chemistry, (Bruice, Paula Y.).
Lihumis, H. S., Mubarak, H. A., Alameri, A. A., & Aowda, S. A. (2022). Synthesis and Diagnosis of Some New Heterocyclic Compounds from Mefenamic Drug and Study of Their Possible Biological Activity.
Mandge, S., Singh, H. P., Gupta, S. D., & Moorthy, N. H. S. N. (2007). Synthesis and characterization of some chalcone derivatives. Trends Appl. Sci. Res, 2(1), 52-56.
Morak-Młodawska, B., Pluta, K., Latocha, M., Jeleń, M., Kuśmierz, D., Suwińska, K., ... & Jurzak, M. (2019). 10 H-1, 9-diazaphenothiazine and its 10-derivatives: synthesis, characterisation and biological evaluation as potential anticancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry, 34(1), 1298-1306.
Nasir Abbas Bukhari, S., Jasamai, M., & Jantan, I. (2012). Synthesis and biological evaluation of chalcone derivatives (mini review). Mini reviews in medicinal chemistry, 12(13), 1394-1403.
Sabre, H. M. (2022). Synthesis and Characterization of Some Novel Oxazine and Thiazine from Acetophenone Derivatives. Journal of Global Scientific Research, 7(4), 2240-2246.
Sadhu, C., & Mitra, A. K. (2023). Synthetic, biological and optoelectronic properties of phenoxazine and its derivatives: a state of the art review. Molecular Diversity, 1-43.
SCHMIDT, R. R. (1972). 1, 3-Oxazines and 1, 3-thiazines, intermediates of interest in organic syntheses. Synthesis, 1972(07), 333-350
Sharma, B. K. (1981). Spectroscopy. Krishna Prakashan Media.
Sharma, Y. R. (2007). Elementary organic spectroscopy. S. Chand Publishing.
Zhuang, C., Zhang, W., Sheng, C., Zhang, W., Xing, C., & Miao, Z. (2017). Chalcone: a privileged structure in medicinal chemistry. Chemical reviews, 117(12), 7762-7810.
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